Our lab focuses on human innate lymphocytes and their diverse functional roles in health, viral infections, cancer and transplantation.

We are currently studying how persistent viruses and immunogenetics regulate innate immune cells through receptors for Human Leukocyte Antigen (HLA) class I, with a particular focus on γδ T cells and NK cells. Specifically, we study the effect of herpesviruses and polymorphisms in HLA and Killer cell Immunoglobulin-like Receptors (KIRs) on the repertoire formation of γδ T cells and other innate lymphocytes as well as their maturation and functional education.

Our approaches combine functional immunology, multidimensional flow cytometry, epigenetics, T-cell receptor repertoire analysis and next-generation gene sequencing.